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1

α–β Chimeric oligo-DNA bearing intercalator-conjugated nucleobase inside the linker sequence remarkably improves thermal stability of an alternate-stranded triple helix

A.T.M. Zafrul Azam, Minoru Hasegawa, Tomohisa Moriguchi, Kazuo Shinozuka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 337 KB

english, 2004

2

Therapeutic effects and side effects in patients with major depression treated with sulpiride once a day

Tohru, Tsukamoto, Mikio, Asakura, Tomohiro, Tsuneizumi, Yuko, Satoh, Takahiro, Shinozuka, Kazuo, Hasegawa

Journal:

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Year:

1994

Language:

english

File:

PDF, 186 KB

english, 1994

3

Graphene field-effect transistor biosensor for detection of biotin with ultrahigh sensitivity and specificity

Wang, Shiyu, Hossain, Md Zakir, Shinozuka, Kazuo, Shimizu, Natsuhiko, Kitada, Shunya, Suzuki, Takaaki, Ichige, Ryo, Kuwana, Anna, Kobayashi, Haruo

Journal:

Biosensors and Bioelectronics

Year:

2020

File:

PDF, 954 KB

2020

4

AvidinâBiotin Technology in Gold Nanoparticle-Decorated Graphene Field Effect Transistors for Detection of Biotinylated Macromolecules with Ultrahigh Sensitivity and Specificity

Wang, Shiyu, Hossain, Md. Zakir, Han, Tao, Shinozuka, Kazuo, Suzuki, Takaaki, Kuwana, Anna, Kobayashi, Haruo

Journal:

Year:

2020

File:

PDF, 5.03 MB

2020

5

UO+ -katalysierte Oligothioadenylat-Synthese mit hoher Regio- und Stereoselektivität

Masamitsu Shimazu, Dr. Kazuo Shinozuka, Prof. Dr. Hiroaki Sawai

Journal:

Angewandte Chemie

Year:

1993

File:

PDF, 385 KB

1993

6

UO-Catalyzed Oligothioadenylate Synthesis with High Regio- and Stereoselectivity

Masamitsu Shimazu, Dr. Kazuo Shinozuka, Prof. Dr. Hiroaki Sawai

Journal:

Angewandte Chemie International Edition

Year:

1993

Language:

english

File:

PDF, 383 KB

english, 1993

7

Synthesis and anti-HIV-1 Activity of Novel 10-Thiaisoalloxazines, a Structural Analogue of C-5 and/or C-6 Substituted Pyrimidine Acyclonucleoside.

Takanori Miyashita, Masanori Baba, Shiro Shigeta, Kenya Mori, Kazuo Shinozuka

Journal:

Year:

2003

File:

PDF, 112 KB

2003

8

Novel Anthraquinone Conjugate (I) of 2,2-Bis(hydroxymethyl)propionic Acid Incorporated to a TFO with Phosphodiester Linkage Facilitates Triplex Formation with dsDNA Bearing a Pyrimidine-Gapped Polypurine Sequence.

Megumi Sato, Tomohisa Moriguchi, Kazuo Shinozuka

Journal:

Year:

2004

File:

PDF, 64 KB

2004

9

ChemInform Abstract: Cholesterol Analogues Labeled with Novel Silylated Fluorescent Compounds

Tomohisa Moriguchi, Masahiro Hosaka, Akihito Yoshinari, Akiko Ozaki, Toshiyuki Takeuchi, Kazuo Shinozuka

Journal:

Year:

2010

File:

PDF, 21 KB

2010

10

Enantiomeric bleomycin model compounds bearing long alkyl-chain

Kazuo Shinozuka, Hiromasa Morishita, Tsutomu Yamazaki, Yukio Sugiura, Hiroaki Sawai

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 289 KB

english, 1991

11

A novel bleomycin model compound bearing hydrophilic steric factor exhibited high oxygen activating capacity

Junya Kohda, Kazuo Shinozuka, Hiroaki Sawai

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 253 KB

english, 1995

12

Synthesis and properties of 2′–5′ and 3′–5′ linked α-oligoriboadenylates

Hiroaki Sawai, Takeshi Ito, Kazumi Kokaji, Masami Shimazu, Kazuo Shinozuka, Hideharu Taira

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 274 KB

english, 1996

13

Synthesis and ribonuclease H related biochemical properties of α-anomeric 2′-deoxypyrimidine homooligomer and its phosphorothioate analog

Kazuo Shinozuka, Nobuaki Yamada, Akiko Nakamura, Hiroaki Ozaki, Hiroaki Sawai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 331 KB

english, 1996

14

Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphodiester linkage facilitates triplex formation with dsDNA bearing a pyrimidine-gapped polypurine sequence

Megumi Sato, Tomohisa Moriguchi, Kazuo Shinozuka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 145 KB

english, 2004

15

Novel fluorescent oligoDNA probe bearing a multi-conjugated nucleoside with a fluorophore and a non-fluorescent intercalator as a quencher

Sinichi Kodama, Satoko Asano, Tomohisa Moriguchi, Hiroaki Sawai, Kazuo Shinozuka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 425 KB

english, 2006

16

Novel sequence-responding fluorescent oligoDNA probe bearing a silylated pyrene molecule

Tohru Sekiguchi, Yumiko Ebara, Tomohisa Moriguchi, Kazuo Shinozuka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 180 KB

english, 2007

17

Novel dinucleoside phosphotriester unit conjugated with an intercalative moiety in a stereospecific manner enhances thermal stability of an alternate-stranded triple helix

Takanori Miyashita, Noritake Matsumoto, Tomohisa Moriguchi, Kazuo Shinozuka

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 252 KB

english, 2003

18

Nucleoside complexing. A13C NMR spectroscopic investigation of the metal binding sites in 7-methylguanosine, 7-methylinosine and some related new synthetic betains

Kazuo Shinozuka, Kenneth Wilkowski, Barbara L. Heyl, Luigi G. Marzilli

Journal:

Inorganica Chimica Acta

Year:

1985

Language:

english

File:

PDF, 983 KB

english, 1985

19

Facile synthesis of nucleotides containing polyphosphates by Mn(II) and Cd(II) ion-catalyzed pyrophosphate bond formation in aqueous solution

Masamitsu Shimazu, Kazuo Shinozuka, Hiroaki Sawai

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 239 KB

english, 1990

20

Synthesis of a novel 2′-deoxyuridine derivative bearing a cyanomethoxycarbonylmethyl group at C-5 position and its use for versatile post-synthetic functionalization of oligodeoxyribonucleotides

Satoru Kohgo, Kazuo Shinozuka, Hiroaki Ozaki, Hiroaki Sawai

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 284 KB

english, 1998

21

Synthesis and RNA cleaving activities of polyamine derived novel artificial ribonuclease

Kazuo Shinozuka, Kazuhiro Shimizu, Yoshimitu Nakashima, Hiroaki Sawai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 308 KB

english, 1994

22

Bi-functional labelling of DNA with tris(2-aminoethyl)amine-derived novel fluorescent agent

Kazuo Shinozuka, Yoshiaki Seto, Hiroyuki Kawata, Hiroaki Sawai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 282 KB

english, 1993

23

Bleomyclin model complex bearing a carbamoyl derived substituent capable of coordination to the chelated metal ion as a sixth ligand

Takayuki Arai, Kazuo Shinozuka, Hiroaki Sawai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 244 KB

english, 1997

24

An approach to prebiotic synthesis of RNA containing α-glycosidic linkage, and properties of the resulting oligo α-RNA

Hiroaki Sawai, Takeshi Ito, Kazumi Kokaji, Kazuo Shinozuka

Journal:

Origins of Life and Evolution of Biospheres

Year:

1996

Language:

english

File:

PDF, 66 KB

english, 1996

25

Current status of intensity-modulated radiation therapy (IMRT)

Kazuo Hatano, Hitoshi Araki, Mitsuhiro Sakai, Takashi Kodama, Naoki Tohyama, Tohru Kawachi, Masaharu Imazeki, Takayuki Shimizu, Tsutomu Iwase, Minoru Shinozuka, Hideyo Ishigaki

Journal:

International Journal of Clinical Oncology

Year:

2007

Language:

english

File:

PDF, 268 KB

english, 2007

26

Second-sphere ‘communication’ between two cis-bound guanine nucleotides. Factors influencing conformations of dynamic adducts of cis-type platinum anticancer drugs with guanine nucleotides as deduced by circular dichroism spectroscopy

Hing C Wong, Kazuo Shinozuka, Giovanni Natile, Luigi G Marzilli

Journal:

Inorganica Chimica Acta

Year:

2000

Language:

english

File:

PDF, 239 KB

english, 2000

27

A nationwide investigation on gestational age specific birthweight and mortality among Japanese twins

Ruoyan Gai Tobe, Rintaro Mori, Norio Shinozuka, Takahiko Kubo, Kazuo Itabashi

Journal:

Paediatric and Perinatal Epidemiology

Year:

2011

Language:

english

File:

PDF, 272 KB

english, 2011

28

A new synthesis of 10-arylisoalloxazines (10-arylflavins)

Fumio Yoneda, Kazuo Shinozuka, Kinshiro Tsukuda, Akira Koshiro

Journal:

Journal of Heterocyclic Chemistry

Year:

1979

File:

PDF, 173 KB

1979

29

An Approach to Prebiotic Synthesis of α-Oligoribonucleotides and Description of Their Properties: Selective Advantage of β-RNA over α-RNA

Sawai, Hiroaki, Itoh, Takeshi, Kokaji, Kazumi, Shinozuka, Kazuo

Journal:

Journal of Molecular Evolution

Year:

1997

Language:

english

File:

PDF, 706 KB

english, 1997

30

A serine proteinase of a fungus isolated from dried bonito “Katsuobushi”

Masato Hiyama, Takashi Ohmoto, Masaaki Shinozuka, Kazuo Ito, Masaru Iizuka, Noshi Minamiura

Journal:

Journal of Fermentation and Bioengineering

Year:

1995

Language:

english

File:

PDF, 638 KB

english, 1995

31

Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway

Stéphane Daviet, Sophie Couvé-Privat, Laurent Gros, Kazuo Shinozuka, Hiroshi Ide, Murat Saparbaev, Alexander A. Ishchenko

Journal:

Year:

2007

Language:

english

File:

PDF, 1017 KB

english, 2007

32

Selective binding of trisamine-modified phosphorothioate antisense DNA to target mRNA improves antisense activity and reduces toxicity

Makoto Matsukura, Tsuyosi Okamoto, Teruhisa Miike, Hiroaki Sawai, Kazuo Shinozuka

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 194 KB

english, 2002

33

Labeling of phosphorothioate antisense oligonucleotides with yttrium-90

Naoyuki Watanabe, Hiroaki Sawai, Keigo Endo, Kazuo Shinozuka, Hiroaki Ozaki, Shuji Tanada, Hajime Murata, Yasuhito Sasaki

Journal:

Nuclear Medicine and Biology

Year:

1999

Language:

english

File:

PDF, 248 KB

english, 1999

34

Regio- and stereocontrolled synthesis of 2???-5??? linked phosphorothioate oligoadenylates by uranyl ion catalyst in aqueous solution

Shimazu, Masamitu, Shinozuka, Kazuo, Sawai, Hiroaki

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2002

Language:

english

File:

PDF, 174 KB

english, 2002

35

SYNTHESIS AND CHARACTERIZATION OF POLYAMINE-BASED BIOMIMETIC CATALYSTS AS ARTIFICIAL RIBONUCLEASE

Shinozuka, Kazuo, Nakashima, Yoshimitu, Shimizu, Kazuhiro, Sawai, Hiroaki

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2001

Language:

english

File:

PDF, 209 KB

english, 2001

36

Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-Stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic β-Cells

Tsuchiya, Miho, Hosaka, Masahiro, Moriguchi, Tomohisa, Zhang, Shaojuan, Suda, Masayuki, Yokota-Hashimoto, Hiromi, Shinozuka, Kazuo, Takeuchi, Toshiyuki

Journal:

Year:

2010

Language:

english

File:

PDF, 386 KB

english, 2010

37

Novel method of the synthesis and hybridization properties of an oligonucleotide containing non-ionic diisopropylsilyl internucleotide linkage

Moriguchi, Tomohisa, Sekine, Mitsuaki, Shinozuka, Kazuo

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 468 KB

english, 2013

38

IS INTERFERON ANY GOOD FOR CANCER?

Tohru, Tsukamoto, Mikio, Asakura, Tomohiro, Tsuneizumi, Yuko, Satoh, Takahiro, Shinozuka, Kazuo, Hasegawa

Journal:

Year:

1981

Language:

english

File:

PDF, 165 KB

english, 1981

39

Involvement of the glutamate receptor δ2 subunit in the long-term depression of glutamate responsiveness in cultured rat Purkinje cells

Hirano, Tomoo, Kasono, Keizo, Araki, Kazuaki, Shinozuka, Kazuo, Mishina, Masayoshi

Journal:

Neuroscience Letters

Year:

1994

Language:

english

File:

PDF, 410 KB

english, 1994

40

Synthesis of phosphorothioate analogues of oligodeoxyribonucleotides and their antiviral activity against human immunodeficiency virus (HIV)

Matsukura, Makoto, Zon, Gerald, Shinozuka, Kazuo, Stein, Cy A., Mitsuya, Hiroaki, Cohen, Jack S., Broder, Samuel

Journal:

Year:

1988

Language:

english

File:

PDF, 489 KB

english, 1988

41

Phosphorothioate Analogs of Oligodeoxynucleotides: Inhibitors of Replication and Cytopathic Effects of Human Immunodeficiency Virus

Makoto Matsukura, Kazuo Shinozuka, Gerald Zon, Hiroaki Mitsuya, Marvin Reitz, Jack S. Cohen and Samuel Broder

Journal:

Proceedings of the National Academy of Sciences

Year:

1987

Language:

english

File:

PDF, 926 KB

english, 1987

42

Regulation of Viral Expression of Human Immunodeficiency Virus in vitro by an Antisense Phosphorothioate Oligodeoxynucleotide against rev (art/trs) in Chronically Infected Cells

Makoto Matsukura, Gerald Zon, Kazuo Shinozuka, Marjorie Robert-Guroff, Takashi Shimada, C. A. Stein, Hiroaki Mitsuya, Flossie Wong-Staal, Jack S. Cohen and Samuel Broder

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 1.19 MB

english, 1989

43

Facile Stereospecific Synthesis of a-Anomeric 2'-Deoxynucleosides

Shinozuka, Kazuo, Hirota, Yoshiki, Morita, Tsutomu, Sawai, Hiroaki

Journal:

Year:

1992

Language:

english

File:

PDF, 159 KB

english, 1992

44

Nucleoside complexing. Evidence for three metastable species in the reaction of nucleosides with cis-dichlorobis(dimethyl sulfoxide)platinum(II). Use of restricted rotation about platinum-nitrogen bonds for structural assignments

Reily, Michael D., Wilkowski, Kenneth, Shinozuka, Kazuo, Marzilli, Luigi G.

Journal:

Inorganic Chemistry

Year:

1985

Language:

english

File:

PDF, 853 KB

english, 1985

45

Platinum antitumor agent coordination chemistry. Syntheses of linked purines and their platinum complexes. Crystal and molecular structures of bis[.mu.-1,4-bis(hypoxanthin-9-yl)butane]bis[(diaminoethane)(platinum(II)] tetrakis(hexafluorophosphate) hydrate

Hey, Barbara L., Shinozuka, Kazuo, Miller, Sandra K., VanDerveer, Donald G., Marzilli, Luigi G.

Journal:

Inorganic Chemistry

Year:

1985

Language:

english

File:

PDF, 852 KB

english, 1985

46

Modification of Second-Sphere Communication, Leading to an Unusually High Abundance of the Head-to-Head Conformer of Cisplatin Cross-Link Retro Models

Saad, Jamil S., Scarcia, Tommaso, Shinozuka, Kazuo, Natile, Giovanni, Marzilli, Luigi G.

Journal:

Inorganic Chemistry

Year:

2002

Language:

english

File:

PDF, 149 KB

english, 2002

47

Synthesis And Anti-HIV Property of Novel Oligo-DNA Phosphorothioate Analogs Bearing an Intercalative Moiety and/Or Polyamine Residues

Shinozuka, Kazuo., Matsukura, Makoto., Okamoto, Tsuyoshi., Sawai, Hiroaki.

Journal:

Nucleosides and Nucleotides

Year:

1998

Language:

english

File:

PDF, 196 KB

english, 1998

48

Synthesis, Characterization, and Biological Properties of 8-Azido- and 8-Amino-Substituted 2‘,5‘-Oligoadenylates

Sawai, Hiroaki, Hirano, Atushi, Mori, Hiroyuki, Shinozuka, Kazuo, Dong, Beihua, Silverman, Robert H.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 116 KB

english, 2003

49

Chemistry of mono(guanine) complexes of cisplatin and its relevance to the N7,O6 chelate hypothesis

Raudaschl-Sieber, Gabriele, Marzilli, Luigi G., Lippert, Bernhard, Shinozuka, Kazuo

Journal:

Inorganic Chemistry

Year:

1985

Language:

english

File:

PDF, 246 KB

english, 1985

50

HMQC and proton and phosphorus-31 NMR studies of platinum amMine adducts of tetradeoxyribonucleotides. Relationship between phosphorus-31 shift and potential hydrogen-bonding interactions in pGpG moieties cross-linked by platinum

Fouts, Christine Spellmeyer, Marzilli, Luigi G., Byrd, R. Andrew, Summers, Michael F., Zon, Gerald, Shinozuka, Kazuo

Journal:

Inorganic Chemistry

Year:

1988

Language:

english

File:

PDF, 1.45 MB

english, 1988

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